2004 - 2005 Publications > Molecular Genetics of Host Response to HIV and HCV

Recent Findings

Molecular Genetics of Host Response to HIV and HCV

• The virion infectivity factor (Vif) accessory protein of HIV-1 forms a complex with the cellular cytidine deaminase APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) to block its antiviral activity. The ability of Vif to block this activity is species-specific.  Landau et al (Salk) reports that A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif).Schrofelbauer et al Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3927-32
• One of the major host factors used to fight hepatitis C and other viral infection are interferons.  Katze et al (U Washington) using aystem-based proteomic analysis of the interferon response in human liver cells have identified new novel cell adhesion proteins, LAMB1 and ADRM, to be induced by interferon. Genome Biol. 2004; 5(8):R54
• Smith et al  have identified a gene expression profile from liver biopsies that predicts rapid progression to cirrhosis in liver transplant patients.  Gastroenterology. 2006 Jan;130(1):179-87

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