2004 - 2005 Publications > Genetics of Opiate Addiction

Recent Findings

Genetics of Opiate Addiction

• Luo et al,  have identified Haplotypes at the OPRM1 locus that are associated with susceptibility to substance dependence is European-Americans.  Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1 120(1):97-108.
• Miller et al  have discovered a mu-opioid receptor single nucleotide polymorphism (C77G) in rhesus monkey: that is associated with stress response and aggression.  Mol Psychiatry. 2004 Jan;9(1):99-108.
• Kest et al,  have mapped quantitative trait locus for morphine withdrawal severity to chromosomes 1, 5 and 10.  Mamm Genome. 2004 Aug;15(8):610-7
• Bart et al  have also shown that a substantial attributable risk related to a functional mu-opioid receptor gene polymorphism A118G is associated with heroin addiction in central Sweden Molecular Psychiatry (2004) 9, 547-549
• Yuserov et al  have shown that human kappa opioid receptor gene (OPRK1) haplotypes are associated with opiate addiction in different ethnic groups and suggest the results are not a consequence of ethnic stratification Pharmacogenetics. 2004 Dec;14(12):793-804
• Proundnikov et al reports that the 1180 G allele of the 5HT1B receptor gene is protective1180G protects caucasions from heroin dependence. Pharmacogenet Genomics. 2006 Jan;16(1):25-36
• Using allele specific gene expression Zhang et al suggest that A118G allele of the mu opioid receptor results in decreased synthesis of the A118G variant of the protein J Biol Chem. 2005 Sep 23;280(38):32618-24. 
• Mogil et al reports that Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans.  J Med Genet. 2005 Jul;42(7):583-7
• Zachariou et al showed that DeltaFosB overexpression in the NAc increased the sensitivity of the mice to the rewarding effects of morphine and led to exacerbated physical dependence, but also reduced their sensitivity to the analgesic effects of morphine and led to faster development of analgesic tolerance. The opioid peptide dynorphin seemed to be one target through which DeltaFosB produced this behavioral phenotype.  Nat Neurosci. 2006 Feb;9(2):205-211
• McClung et al used microarrays of tissue from specific brain regions involved in morphine responses to identify clusters of genes regulated by chronic morphine and morphine withdrawal.  J Neurosci. 2005 Jun 22;25(25):6005-15
• Chen et al  Found that a signaling cascade composed of Trka/PI3 kinase/AKT1/NF kappa beta mediates delta opioid receptor expression. J Biol Chem. 2005 Nov 29
• Ippolito et al  Found that pain and behavioral stress induce tyrosine phosphorylation of the potassium channel Kir3.1 likely leading to physiological adaptation J Biol Chem. 2005 Dec 16;280(50):41683-93
• Fan et al  showed that delta and mu opioid receptor heterooligomers have properties distinct from delta or mu homooligomers. J Biol Chem. 2005 Nov 18;280(46):38478-88

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