2008 - 2009 Publications >Genetics of drug abuse and addiction vulnerability

Recent Findings

Genetics of Drug Abuse and Addiction Vulnerability.

• Principal component analyses indicated that the 6 individual variables of lifetime symptom counts of alcohol dependence, illicit drug dependence, childhood conduct disorder, and adult antisocial personality disorder and novelty seeking, sensation seeking loaded on a single externalizing factor. Linkage analyses using the resultant component scores identified a region on chromosome 7 consistent with a gene, CHRM2 that broadly predisposes individuals to externalizing behavior. Dick et al Arch Gen Psychiatry. 2008 Mar;65(3):310-8

• Analysis of twins in the Virginia twin registry suggests that substantial correlations seen in levels of use of alcohol, caffeine, cannabis, and nicotine are largely the result of social environmental factors in adolescence,with genetic factors becoming progressively more important through early and middle adulthood. Kendler et al Arch Gen Psychiatry. 2008 Jun;65(6):674-82

NIDA Genetics Programs

•	Home Page
•	About Genetics Workgroup
•	Human Genetics Application Guidelines
•	NIDA Genetics News
•	NIDA Genetics Consortium
•	NIDA Recent Findings
•	NIDA Genetics Portfolio
•	NIDA Genetics Reports
•	NIDA Initiatives in Genetics
•	NIDA Meetings
•	NIDA Program Contacts

Resources for Genetics, Cell Biology, and Neuroscience

•	Calendar
•	Genetics Consortia
•	Human Genetics
•	Tissue and Cell Repositories
•	Twin Registry
•	Nucleotide
•	Gene Expression
•	Genomes
•	Proteins
•	Model Organisms
•	Mouse
•	Knowledgebase for Addiction Related Genes (KARG)
•	Cell Biology
•	Neuroscience Information Framework
•	Bibliographic Resources